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Physical plasma in medicine

 

For many years argon plasma units are in use in gastroenterology and surgery e. g. for endoscopic oozing of inner bleedings, liver resections and polypectomies. Plasma coagulation uses the contact free effects of hot plasmas to ooze bleedings. Cold tissue-tolerated plasma of the kINPen® MED allows a direct therapeutically application on the skin without anaesthesia. In this new technology longstanding research succeed to generate a stable plasma at a very low temperature of about 40 °C.

Since 2013 plasma therapy with the kINPen® MED is applied successful in medicine and is considered an effective treatment method in particular for infected, poor healing wounds and pathogen-induced skin diseases.

 

 

Effect mechanism of plasma therapy

 

By the synergistic combination of different active plasma components like applying excited gas species (for example excited oxygen and nitrogen molecules), a low-level UV light irradiation, a current flow and a short topical increase in temperature a strong antimicrobial effect is generated at the surface treated by the plasma jet. This effect leads to a disruption of the cell membrane of typical wound pathogens and multiresistant bacteria.

 

 

Indication and advantages

 

Cold plasma treatment with the kINPen® MED is suitable in particular for chronic, infected wounds like Ulcus crusis or decubital ulcer, as well as skin diseases caused by pathogens, for example Acne vulgaris or Tinea pedis.

Wound healing is stimulated and accelerated by supporting cell proliferation during the treatment. Data from studies prove the high effectiveness on typical wound pathogens and multiresistant bacteria like Pseudomonas, Klebsiellae or Methicillin-resistant S.-aureus.

The plasma pen generates hand-warm plasma, which is very well tolerated, painless and easy to use. During the studies no side effects or resistance formation was observed.

 

 

Plasma treatment with kINPen® MED

 

The plasma jet kINPen® MED is easy to operate. After plug on the spacer, the plasma pen will be swept vertically over the affected skin area in a steady pace of about 5mm per second. The treatment will be repeated after a few days (one to two times per week) until the desired result is recognizable. The plasma treatment can and should be applied adjuvant to other forms of therapy like topical drug therapy or tissue excision depending on the treating physician advice.

Especially highly necrotic wounds first require a classic-mechanic debridement before cold plasma could be applied. To avoid unintended side effects we recommend applying the plasma treatment before a topical drug therapy.

 

 

Clinical trials and case studies

 

Since 2005 several clinical studies or case studies about the application of cold plasma on skin and on acute and chronic wounds in Germany among others in Munich/Schwabing, Goettingen, Regensburg, Berlin and Greifswald were documented or published.

Up to now no unintended side effects were observed as a result of this type of plasma treatment. Differnet in vitro and in vivo investigations proved the high antimicrobial effect. Even on multi-resistant pathogens no clinical relevant differences were observed concerning the effectiveness:

 

 • Effective against typical wound pathogens (Daeschlein G, et al., 2012):

 • Destruction of all 105 investigated, typical wound germs and typical problem-causing pathogens like Pseudomonas, Klebsiellae, Methicillin-resistant S. aureus.

 • Median of relative decreasing wound size in treatment of chronic leg ulcer (Ulrich C, et al., in publication): Treatment with kINPen® MED and Octenisept©: plasma therapy: 56 %, Octenisept© therapy: 19 %,

 • Supporting cell proliferation by stimulation with cold plasma (Kalghatgi S, et al., 2010),

 • Very well tolerated, no side effects of formation of resistance observed (Daeschlein G, et al., 2012)

For further information about clinical studies, case studies and publications please read the pdf file.

Contactt

 

For technical question please contact me::

 

Sven Nabers
Tel. +49 3834 515 211
Fax +49 3834 515 209
sven.nabers@neoplas-tools.eu

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Our distribution partners will be pleased to inform you about the neoplas tools products and services:

 

Distribution Germany

neoplas tools GmbH
Walther-Rathenau-Str. 49a
17489 Greifswald, Germany

 

Contact:

Sven Nabers
Tel. +49 3834 515 211
Fax +49 3834 515 209
sven.nabers@neoplas-tools.eu

 

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Tel. +49 3834 515 211
Fax +49 3834 515 209
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12203 Berlin, Deutschland

 

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Monsatec AG
Executive Board:

Jianhe Mao & Niklaus Sauter
Bienenstr. 20
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Contact:

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Büro +41 (79) 357 47 07
Tel. +41 (79) 2544 228
jianhe.mao@monsatec.ch

 

Niklaus Sauter

Büro +41 (79) 357 47 07
Tel. +41 (79) 408 9320
niklaus.sauter@monsatec.ch

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